Topoisomerase I Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE02703
Supplier Catalog Number:
AMRe02703
Alternative Catalog Number:
EKL-AMRE02703-50UL, EKL-AMRE02703-100UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
ICC, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
TOP1, DNA topoisomerase 1, DNA topoisomerase I
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5-OH DNA strand.
