Phospho-Chk1 (S296) (14A3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05875
Produktübersicht
Artikelname:
Phospho-Chk1 (S296) (14A3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05875
Hersteller Artikelnummer:
AMRe05875
Alternativnummer:
EKL-AMRE05875-50UL, EKL-AMRE05875-100UL, EKL-AMRE05875-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog (S. pombe), Serine/threonine-protein kinase Chk1,
Produktbeschreibung
Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression. Activation of Chk1 involves phosphorylation at Ser317 and Ser345 by ATM/ATR, followed by autophosphorylation of Ser296. Activation occurs in response to blocked DNA replication and certain forms of genotoxic stress. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047, PubMed: 32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed: 11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed: 11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047). Recognizes the substrate consensus sequence [R-X-X- S/T] (PubMed: 11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed: 9278511, PubMed: 12676583, PubMed:
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
54kDa
NCBI:
1111
UniProt:
O14757
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
CHEK1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000
