Phospho-SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06005
Produktübersicht
Artikelname:
Phospho-SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06005
Hersteller Artikelnummer:
AMRe06005
Alternativnummer:
EKL-AMRE06005-50UL, EKL-AMRE06005-100UL, EKL-AMRE06005-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IP, WB
Spezies Reaktivität:
Human, Mouse
Konjugation:
Unconjugated
Alternative Synonym:
BPTP3, CFC, MGC14433, NS1, PTN11, PTP-1D, PTP-2C, PTP2C, PTPN11, SH-PTP2, SH-PTP3, SHP-2, Shp2, SHPTP2,
Produktbeschreibung
SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed: 18559669, PubMed: 18829466, PubMed: 26742426, PubMed: 28074573). Positively regulates MAPK signal transduction pathway (PubMed: 28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed: 28074573). Dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity (PubMed: 18559669). Dephosphorylates CDC73 (PubMed: 26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
68kDa
NCBI:
5781
UniProt:
Q06124
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
PTPN11
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,ICC/IF 1:100-1:200,IP 1:20-1:50
