Phospho-SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE06005
Product Overview
Article Name:
Phospho-SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE06005
Supplier Catalog Number:
AMRe06005
Alternative Catalog Number:
EKL-AMRE06005-50UL, EKL-AMRE06005-100UL, EKL-AMRE06005-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
ICC, IP, WB
Species Reactivity:
Human, Mouse
Conjugation:
Unconjugated
Alternative Names:
BPTP3, CFC, MGC14433, NS1, PTN11, PTP-1D, PTP-2C, PTP2C, PTPN11, SH-PTP2, SH-PTP3, SHP-2, Shp2, SHPTP2,
Product Description
SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed: 18559669, PubMed: 18829466, PubMed: 26742426, PubMed: 28074573). Positively regulates MAPK signal transduction pathway (PubMed: 28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed: 28074573). Dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity (PubMed: 18559669). Dephosphorylates CDC73 (PubMed: 26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
68kDa
NCBI:
5781
UniProt:
Q06124
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
PTPN11
Application Notes
Application Dilute:
WB 1:500-1:2000,ICC/IF 1:100-1:200,IP 1:20-1:50
