Aconitase 1 (7U6) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06511
Produktübersicht
Artikelname:
Aconitase 1 (7U6) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06511
Hersteller Artikelnummer:
AMRe06511
Alternativnummer:
EKL-AMRE06511-50UL, EKL-AMRE06511-100UL, EKL-AMRE06511-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, ICC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
ACO 1, Aconitase, Citrate hydro lyase, IREB1, IRP 1, Iron responsive element binding protein 1,
Produktbeschreibung
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed: 1281544, PubMed: 8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
98kDa
NCBI:
48
UniProt:
P21399
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
ACO1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:200
