Aconitase 1 (7U6) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE06511
Product Overview
Article Name:
Aconitase 1 (7U6) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE06511
Supplier Catalog Number:
AMRe06511
Alternative Catalog Number:
EKL-AMRE06511-50UL, EKL-AMRE06511-100UL, EKL-AMRE06511-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
ACO 1, Aconitase, Citrate hydro lyase, IREB1, IRP 1, Iron responsive element binding protein 1,
Product Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed: 1281544, PubMed: 8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
98kDa
NCBI:
48
UniProt:
P21399
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
ACO1
Application Notes
Application Dilute:
WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:200
