BIN1 (14G10) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE07564
Artikelname: BIN1 (14G10) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE07564
Hersteller Artikelnummer: AMRe07564
Alternativnummer: EKL-AMRE07564-50UL, EKL-AMRE07564-100UL, EKL-AMRE07564-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: FC, ICC, IHC, IP, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: AMPH2, Amphiphysin 2, Amphiphysin II, AMPHL, Bin1, Bridging integrator 1, SH3P9,
May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation. Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
Klonalität: Monoclonal
Molekulargewicht: 65kDa
NCBI: 274
UniProt: O00499
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: BIN1
Application Verdünnung: WB 1:1000-1:5000,IHC 1:100-1:500,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50



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