CD105 (15P10) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE08183
Artikelname: CD105 (15P10) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE08183
Hersteller Artikelnummer: AMRe08183
Alternativnummer: EKL-AMRE08183-50UL, EKL-AMRE08183-100UL, EKL-AMRE08183-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: IF, IHC, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: CD105, END, Endoglin, Eng, HHT1, ORW, ORW1, SN6,
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Klonalität: Monoclonal
Molekulargewicht: 71kDa
NCBI: 2022
UniProt: P17813
Puffer: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: ENG
Application Verdünnung: WB 1:1000-1:5000,IHC 1:200-1:500,IF-P 1:200-1:500



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