CD105 (15P10) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE08183
Article Name: CD105 (15P10) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE08183
Supplier Catalog Number: AMRe08183
Alternative Catalog Number: EKL-AMRE08183-50UL, EKL-AMRE08183-100UL, EKL-AMRE08183-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: IF, IHC, WB
Species Reactivity: Human
Conjugation: Unconjugated
Alternative Names: CD105, END, Endoglin, Eng, HHT1, ORW, ORW1, SN6,
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Clonality: Monoclonal
Molecular Weight: 71kDa
NCBI: 2022
UniProt: P17813
Buffer: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Purity: Affinity purification
Form: Liquid
Target: ENG
Application Dilute: WB 1:1000-1:5000,IHC 1:200-1:500,IF-P 1:200-1:500



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