CD11b (8E1) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE08196
Artikelname: CD11b (8E1) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE08196
Hersteller Artikelnummer: AMRe08196
Alternativnummer: EKL-AMRE08196-50UL, EKL-AMRE08196-100UL, EKL-AMRE08196-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: FC, ICC, IHC, IP, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6,
ITGAM, also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. ITGAM is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Klonalität: Monoclonal
Molekulargewicht: 127kDa
NCBI: 3684
UniProt: P11215
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: ITGAM
Application Verdünnung: WB 1:2000-1:10000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50



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