CD11b (8E1) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE08196
Article Name: CD11b (8E1) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE08196
Supplier Catalog Number: AMRe08196
Alternative Catalog Number: EKL-AMRE08196-50UL, EKL-AMRE08196-100UL, EKL-AMRE08196-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: FC, ICC, IHC, IP, WB
Species Reactivity: Human
Conjugation: Unconjugated
Alternative Names: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6,
ITGAM, also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. ITGAM is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Clonality: Monoclonal
Molecular Weight: 127kDa
NCBI: 3684
UniProt: P11215
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: ITGAM
Application Dilute: WB 1:2000-1:10000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50



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