CD14 (16H16) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE08209
Produktübersicht
Artikelname:
CD14 (16H16) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE08209
Hersteller Artikelnummer:
AMRe08209
Alternativnummer:
EKL-AMRE08209-50UL, EKL-AMRE08209-100UL, EKL-AMRE08209-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
CD14, Monocyte differentiation antigen CD14, Myeloid cell specific leucine rich glycoprotein,
Produktbeschreibung
CD14 antigen is a GPI-linked glycoprotein with a molecular weight of 55kD. The CD14 antigen is expressed on cells of the myelomonocytic lineage including monocytes, macrophages and Langerhans cells. Low expression is observed on neutrophils and on human B cells. CD14 antigen is a receptor for bacterial lipopolysaccharide (LPS, endotoxin) and the lipopolysaccharide binding protein (LBP). LBP and CD14 antigen serves two physiological roles. Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed: 23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed: 20133493, PubMed: 23264655, PubMed: 22265692). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed: 8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed: 16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed: 23880187).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
40kDa
NCBI:
929
UniProt:
P08571
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
CD14
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,IHC 1:200-1:2000
