CD14 (16H16) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE08209
Product Overview
Article Name:
CD14 (16H16) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE08209
Supplier Catalog Number:
AMRe08209
Alternative Catalog Number:
EKL-AMRE08209-50UL, EKL-AMRE08209-100UL, EKL-AMRE08209-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
CD14, Monocyte differentiation antigen CD14, Myeloid cell specific leucine rich glycoprotein,
Product Description
CD14 antigen is a GPI-linked glycoprotein with a molecular weight of 55kD. The CD14 antigen is expressed on cells of the myelomonocytic lineage including monocytes, macrophages and Langerhans cells. Low expression is observed on neutrophils and on human B cells. CD14 antigen is a receptor for bacterial lipopolysaccharide (LPS, endotoxin) and the lipopolysaccharide binding protein (LBP). LBP and CD14 antigen serves two physiological roles. Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed: 23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed: 20133493, PubMed: 23264655, PubMed: 22265692). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed: 8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed: 16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed: 23880187).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
40kDa
NCBI:
929
UniProt:
P08571
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
CD14
Application Notes
Application Dilute:
WB 1:1000-1:5000,IHC 1:200-1:2000
