Niemann Pick C1 (4L10) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE14699
Produktübersicht
Artikelname:
Niemann Pick C1 (4L10) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE14699
Hersteller Artikelnummer:
AMRe14699
Alternativnummer:
EKL-AMRE14699-50UL, EKL-AMRE14699-100UL, EKL-AMRE14699-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, ICC, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
Niemann Pick C1 protein precursor, NPC, NPC1,
Produktbeschreibung
Involved in the intracellular trafficking of cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed: 9927649, PubMed: 10821832, PubMed: 18772377, PubMed: 27238017, PubMed: 12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed: 9211849, PubMed: 9927649, PubMed: 18772377, PubMed: 19563754, PubMed: 27238017, PubMed: 28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed: 19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
142kDa
NCBI:
4864
UniProt:
O15118
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
NPC1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:50-1:100,FC 1:100-1:200
