Niemann Pick C1 (4L10) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE14699
Product Overview
Article Name:
Niemann Pick C1 (4L10) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE14699
Supplier Catalog Number:
AMRe14699
Alternative Catalog Number:
EKL-AMRE14699-50UL, EKL-AMRE14699-100UL, EKL-AMRE14699-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
Niemann Pick C1 protein precursor, NPC, NPC1,
Product Description
Involved in the intracellular trafficking of cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed: 9927649, PubMed: 10821832, PubMed: 18772377, PubMed: 27238017, PubMed: 12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed: 9211849, PubMed: 9927649, PubMed: 18772377, PubMed: 19563754, PubMed: 27238017, PubMed: 28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed: 19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
142kDa
NCBI:
4864
UniProt:
O15118
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
NPC1
Application Notes
Application Dilute:
WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:50-1:100,FC 1:100-1:200
