GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of beta-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus, MSSA: methicillin-sensitive S. aureus
Molekulargewicht:
454.45
Reinheit:
99.85
CAS Nummer:
[551919-98-3]
Formel:
C22H21F3N8
Target-Kategorie:
Apoptosis,Aurora Kinase,Bacterial
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
