GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of beta-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus, MSSA: methicillin-sensitive S. aureus
Molecular Weight:
454.45
Purity:
99.85
CAS Number:
[551919-98-3]
Formula:
C22H21F3N8
Target:
Apoptosis,Aurora Kinase,Bacterial
Application Notes:
MCE Product type: Reference compound
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