SBI-581 is an orally active, selective inhibitor of the serine/threonine kinase TAO3 with an IC50 value of 42 nM and antitumor activity. SBI-581 promotes the accumulation of TKS5alpha in RAB11-positive vesicles and inhibits the formation of invasive pseudopods, thereby suppressing the invasive and migratory capabilities of tumor cells. The pharmacokinetic profile of SBI-581 following intraperitoneal administration in mice is reasonable.
Molekulargewicht:
383.44
Formel:
C24H21N3O2
Target-Kategorie:
Serine Protease
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
