SBI-581 is an orally active, selective inhibitor of the serine/threonine kinase TAO3 with an IC50 value of 42 nM and antitumor activity. SBI-581 promotes the accumulation of TKS5alpha in RAB11-positive vesicles and inhibits the formation of invasive pseudopods, thereby suppressing the invasive and migratory capabilities of tumor cells. The pharmacokinetic profile of SBI-581 following intraperitoneal administration in mice is reasonable.
Molecular Weight:
383.44
Formula:
C24H21N3O2
Target:
Serine Protease
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