Clk4 Antibody - N-terminal region

Catalog Number: ASB-ARP30646_P050
Article Name: Clk4 Antibody - N-terminal region
Biozol Catalog Number: ASB-ARP30646_P050
Supplier Catalog Number: ARP30646_P050
Alternative Catalog Number: ASB-ARP30646_P050-25UL,ASB-ARP30646_P050-100UL
Manufacturer: Aviva
Host: Rabbit
Category: Proteine/Peptide
Application: WB
Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
Alternative Names: C85119, AI987988
Clk4 is a dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Clk4 phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Clk4 phosphorylates SRSF1 and SRSF3. Clk4 is required for the regulation of alternative splicing of MAPT/TAU. Clk4 regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Clonality: Polyclonal
Concentration: 0.5 mg/ml
Molecular Weight: 57 kDa
NCBI: 12750
UniProt: O35493
Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Host: Rabbit
Target Name: Clk4
Antibody Dilution: 0.25ug/ml
Sample Type: Mouse Pancreas
Surface Plasmon Resonance Kinetic Characterization of Polyclonal Antibody Affinity. Purified polyclonal antibodies were immobilized on a Protein A/G coated Carterra LSA sensor chip (PAGH200M) at concentrations of 5, and 50 ug/mL in duplicate. Antibodies on the surface were exposed to interaction with peptides sequentially via microfluidic controlled flow at 333nM peptide concentration for kinetic characterization of the binders for affinity and specificity, followed by curve fitting using the Kinetics software. Kd determinations for both concentrations were averaged and results and standard deviation are shown.
Clk4 antibody - N-terminal region (ARP30646_P050) in Mouse Pancreas using Western Blot