Bovine, Canine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human CMA1
Alternative Names:
CYH, MCT1, chymase
CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.
WB Suggested Anti-CMA1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysateCMA1 is supported by BioGPS gene expression data to be expressed in COLO205
CMA1 antibody - C-terminal region (ARP59991_P050) in Human COLO205 using Western Blot
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