MOCS3 Antibody
Catalog Number:
ASB-OACA08343
- Images (3)
| Article Name: | MOCS3 Antibody |
| Biozol Catalog Number: | ASB-OACA08343 |
| Supplier Catalog Number: | OACA08343 |
| Alternative Catalog Number: | ASB-OACA08343-100UL,ASB-OACA08343-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3 protein (271-460AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | adenylyltransferase and sulfurtransferase MOCS3,molybdenum cofactor synthesis protein 3,molybdopterin synthase sulfurylase,MPT synthase sulfurylase,UBA4,UBA4, ubiquitin-activating enzyme E1 homolog,ubiquitin-like modifier activating enzyme 4. |
| Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor, NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. |
| Clonality: | Polyclonal |
| NCBI: | 27304 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human liver tissue at dilution 1:100 |
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Western blot All lanes: MOCS3 antibody at 4.25ug/ml Lane 1A: A549 whole cell lysate |
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