Recombinant Human E3 ubiquitin-protein ligase RNF5 protein (1-120AA)
Conjugation:
Unconjugated
Alternative Names:
E3 ubiquitin-protein ligase RNF5,protein G16,ram1 homolog,RING finger protein 5,ring finger protein 5, E3 ubiquitin protein ligase,RING5,RING-type E3 ubiquitin transferase RNF5,RMA1.
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD, the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the Lys-48-linked polyubiquitination of TMEM173 at Lys-150 leading to its proteasomal degradation, the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses.