Phospho-Chk1 (S280) (9M10) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE05874
Product Overview
Article Name:
Phospho-Chk1 (S280) (9M10) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE05874
Supplier Catalog Number:
AMRe05874
Alternative Catalog Number:
EKL-AMRE05874-50UL, EKL-AMRE05874-100UL, EKL-AMRE05874-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
Checkpoint kinase 1, Chek1, Chk1, rad27,
Product Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047, PubMed: 32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed: 11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed: 11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047). Recognizes the substrate consensus sequence [R-X-X- S/T] (PubMed: 11535615, PubMed: 12446774, PubMed: 12399544, PubMed: 14559997, PubMed: 14988723, PubMed: 15311285, PubMed: 15665856, PubMed: 15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed: 9278511, PubMed: 12676583, PubMed: 14681206, PubMed:
Product Properties
Clonality:
Monoclonal
Molecular Weight:
54kDa
NCBI:
1111
UniProt:
O14757
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
CHEK1
Application Notes
Application Dilute:
WB 1:1000-1:5000
